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Education

• Postdoctoral Training, Harvard School of Public Health
• Ph.D. Mechanics of Solids and Structures, Brown University
• M.S. Applied Mathematics, Brown University
• M.Tech. Mechanical Engineering, Indian Institute of Technology, Madras
• B.S. Mechanical Engineering, University of Pune

Research

An overarching goal of my research lab is to apply the principles of mechanics and material science to identify the physical rules that govern the function of cells, tissues, and organs. While seeking to identify the fundamental rules of life, we invest significant efforts in using automation technologies to build innovative products for life sciences researchers and healthcare providers.

As part of the Center for Lung Biology team, we primarily focus on the mechanobiology of lungs. Several of our ongoing projects involve identifying the physical laws that govern migration, deformation, division, detachment and death of lung endothelial cells. These projects are designed to (a) improve our understanding of the basic science of the endothelial cells, (b) identify novel mechanical modulators of lung pathologies including pulmonary hypertension, sepsis, and acute lung injury.

Publications

• A Nguyen, K Battle, SS Paudel, N Xu, J Bell, L Ayers, C Chapman, AP Singh, S Palanki, T Rich, DF Alvarez, T Stevens, DT Tambe, Journal of Visualized Experiments, (181) e63095, 2022
• N Xu, L Ayers, V Pastukh, M Alexeyev, T Stevens, DT Tambe, Public Library of Sciences - One 16 (4), e0250095, 2021
• NG Patel, A Nguyen, N Xu, S Ananthasekar, DF Alvarez, T Stevens, DT Tambe Biochemical and Biophysical Research Communications, 522 (2), 279-285 2020
• G Patel, N Xu, A Nguyen, DF Alvarez, JJ Fredberg, T Stevens, DT Tambe Biochemical and Biophysical Research Communications, 519 (2), 337-343 2019
• 
  DT Tambe, CC Hardin, TE Angelini, K Rajendran, CY Park, ...
  Nature materials 10 (6), 469 547 2011 
• 
  DT Tambe, U Croutelle, X Trepat, CY Park, JH Kim, E Millet, JP Butler, ...
  Public Library of Sciences - One 8 (2), e55172 86 2013 
• 
  CC Hardin, J Chattoraj, G Manomohan, J Colombo, T Nguyen, D Tambe, ... Biochemical and biophysical research communications 495 (1), 749-754 2018 
• 
  CY Park, EH Zhou, D Tambe, B Chen, T Lavoie, M Dowell, A Simeonov, ...
  Integrative Biology 7 (10), 1318-1324 33 2015

Patents

• 
  DT Tambe, JJ Fredberg, J Butler, X Trepat
  US Patent 9,714,932 2017
• 
  DT Tambe, N Patel
  Patent filed

For additional Publications:

Courses

• EG 315 - Mechanics of Materials
• ME 314- Machine Component Design
• ME 410 - Principles of Design
• ME 490 - Cell Mechanics
• ME 583 - Applied Elasticity
• ME 490/590 / IDL 590 - Introduction to Digital Image Processing in Automation and Biomedical Engineering
• IDL 635 - Advanced Signal Transduction (module on Mechanical Signaling in the Cells)

Directed Independent Study on the following topics:

• Bioengineering
• Biomechanics
• Automation Technology

Faculty Advisor: Society of Women Engineers, Jaguar Cricket Club